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As part of the residency program in otolaryngology, each resident participates in a dedicated four month research block as part of the PGY-3 year. This part of the educational curriculum exposes residents to cutting edge techniques of basic science research and provides for an understanding of how new knowledge is acquired.
Residents have the opportunity to choose from the several projects currently being carried out by department faculty or to spend this time in any other department of the university. The department hosts an annual Research Day in March. In addition, the department will sponsor residents who travel to meetings to present original research. Many faculty members maintain interest in clinical research, and residents are encouraged to participate in these investigations throughout their residency.
- Resident Research Day brochure 2005 (PDF)
- Resident Research Day brochure 2006 (PDF)
- Resident Research Day brochure 2007 (PDF)
Samantha Anne, MD
Hall, KL, Anne, S, Semaan, MT, Pitts, D, Alagramam, K, Megerian, CA, RNA detection
from archival guinea pig temporal bone specimens
Manuscript submitted to Molecular Brain Research 2005
Anne, S, Semaan, MT, Alagramam, K, Megerian, CA, Expression analysis of GLAST and GS genes in hydropic ears in the guinea pig model
Manuscript in preparation 2005
Hall, KL, Anne, S, Pitts, D, Alagramam, K, Megerian, CA, Optimization of RNA detection from archival guinea pig temporal bone specimens
Abstract submitted to AOS, September 2004.
Drescher, MJ, Cho, WJ, Anne, S, Adenyly-cyclase mediated signal transduction in saccular hair cells: coupling to GalphaS/olf. Presented at annual ARO meeting, February 2002.
Ahsan, S, Khan, KM, Anne, S, Haupart, M, Efficacy of routine chest x ray following tracheotomy in children. Presented at annual ASPO meeting, May 2001.
2004-2005 Otology Lab Department of Otolaryngology, Head and Neck Surgery, Case Western Reserve University, Cleveland, OH. Sponsor: Alagramam, K, PhD, Megerian CA, MD Investigation of molecular biology of deafness in the animal model of endolymphatic hydrops.
2001, July-Aug. NIH Research Training in Otolaryngology Department of Otolaryngology, Head and Neck Surgery, Wayne State University, Detroit, MI. Sponsor: Drescher, MJ, PhD. Investigation of cDNA from microdissected cochlear subfractions and cDNA libraries for inner and outer hair cells to determine expression of adenylyl cyclase type VIII and splice variants with PCR.
Brian Drew, MD
Drew BR, Semaan MT, Hsu DP, Megerian CA. Endolymphatic Duct Violation During Middle Fossa Dissection of the Internal Auditory Canal: A Human Temporal Bone Radiographic Study. Laryngoscope (In Press).
Nitin Pagedar, MD
January 2006: “Gene expression analysis of distinct populations of cells isolated from
mouse and human inner ear FFPE tissue using Laser Capture Microdissection.” Brain
Research ePub 2006 Mar 8.
December 2005: “Microtia and aural atresia.” Grand rounds, Department of
Otolaryngology – Head and Neck Surgery, Case Western Reserve University.
November 2005: “An unusual presentation of Teflon granuloma.” In press, ENT Journal.
May 2005: “Management of thyroid neoplasms.” Grand rounds, Department of
Otolaryngology – Head and Neck Surgery, Case Western Reserve University.
May 2005: “Gene expression analysis in specific inner ear functional domains using
Laser Capture Microdissection.” Presentation, North East Ohio Otolaryngology – Head
and Neck Surgery Society Resident Research Competition.
April 2005: “Gene expression analysis in specific inner ear functional domains using
Laser Capture Microdissection.” Poster, ShowCASE, Case Western Reserve University.
March 2005: “Gene expression analysis in specific inner ear functional domains using
Laser Capture Microdissection.” Presentation, Department of Otolaryngology – Head and
Neck Surgery Research Day, Case Western Reserve University.
March 2005: “Gene expression analysis in specific inner ear functional domains using
Laser Capture Microdissection.” Presentation, University of Pittsburgh Alumni Day and
Refresher Course.
May 2004: “Maxillofacial trauma.” Grand rounds, Department of Otolaryngology – Head
and Neck Surgery, Case Western Reserve University.
Maroun Semaan, MD
Semaan MT, Alagramam KN, Megerian CA. The basic science of
Meniere’s disease and endolymphatic hydrops. Current opinion in Otolaryngology and Head and Neck Surgery, 2005, Oct; 13:301-7.
Sulman CG, Vecchiotti MA, Semaan MT, Lewin JS, Megerian CA.
Endolymphatic duct violation during retrosigmoid dissection of the internal auditory
canal: a human temporal bone radiographic study. Laryngoscope, 2004 Nov;
114(11):1936-40.
Faress JA, McKinney LA, Semaan MT, Byrd RP Jr, Mehta JB, Roy TM.
Mycobacterium xenopi pneumonia in the southeastern United States; South Med J.
2003 Jun; 96(6):596-9.
Drew BR, Semaan MT, Hsu DP, Megerian CA. Endolymphatic Duct Violation during Middle Fossa Dissection of the Internal Auditory Canal. Laryngoscope. Mar 2006; 116(3):370-4
Weber DA, Semaan MT, Megerian CA. Calcium Alginate Patches in the Repair of the Chinchilla Tympanic Membrane Perforation. Laryngoscope. May 2006;116(5): Hall K, Pitts D, Anne S, Semaan M, Alagramam K, Megerian C. Optimization of RNA Detection from Archival Guinea Pig Temporal Bone Specimens. Otology and Neuro-otology (accepted)
Zurcher MA, Young DJ, Semaan MT, Megerian CA, Ko WH. Development of Middle Ear Acoustic Sensor for Fully Implantable Cochlear Prosthesis. International Conference on Networked Sensing Systems, pp.49-54, Chicago, May-June, 2006.
Zurcher MA, Young DJ, Semaan MT, Megerian CA, Ko WH. Effect of Incus Removal on Middle Ear Acoustic Sensor for a Fully Implantable Cochlear Prosthesis. Engineering in Medicine and Biology Conference. New York. August-September, 2006.
Semaan MT, Megerian CA. Pathophysiology of Middle Ear Cholesteatoma. Otolaryngologic Clinics of North America. Vol 39. Issue 6. December 2006. (accepted review paper) 700-4.
Poster Presentations:
Weber DA, Semaan MT (presenter), Megerian CA. Calcium Alginate Patches in the Repair of the Chinchilla Tympanic Membrane Perforation. Triological Society Meeting Western and Middle Section. San Diego. Feb 2006.
Kianoush Sheykholeslami, MD, PhD
Sheykholeslami K, Kaga K, Tsuzuku T, Mizutani M. Electrophysiological measures of auditory function in the neurofilament-deficient mutant quail (Quv). 2001, Hearing
Research. 2001 Sep; 159(1-2):117-246.
Sheykholeslami K, Habiby Kermany M, Kaga K. Bone-conducted vestibular evoked
myogenic potentials in patient with congenital atresia of the external auditory canal.
International journal of Pediatric Oto-Rhino-Laryngolgy. 2001; 57, 25-29.
Sheykholeslami K, Kaga K, Kaga M. An isolated and sporadic auditory neuropathy: A report of five patients. Journal of Laryngology and Otology. 2001 Jul;115(7):530-534.
Sheykholeslami K, Habiby Kermany M, Kaga K. Frequency sensitivity range of the
saccule to bone-conducted stimuli measured by vestibular evoked myogenic potentials. Hearing Research. 2001 Oct; 160:58-62.
Sheykholeslami K, Kaga K, Mizutani M. Auditory nerve fiber differences in the
normal and neurofilament deficient Japanese quail. Hearing Research. 2001 Sep; 159(1-2): 117-124.
Sheykholeslami K, Kaga K. The otolith organ as a receptor of vestibular hearing
revealed by vestibular evoked myogenic potentials in patients with inner ear anomalies. Hearing Research. 2002. Mar; 165(1-2):62-67.
Pourbakht A, Sheykholeslami K, Kaga K. Distortion evoked otoacoustic emission
using GSI 70 analyzer for neonatal screening. International Journal of Pediatric Oto-Rhino-Laryngolgy, 2002, Jul 9; 64(3):217-23.
Kaga K, Sheykholeslami K . Auditory neuropathy. New Medicine. 2002.
Sheykholeslami K. Bone-conducted binaural interaction. The journal of Iranian Audiology. 2002.
Schmerber S, Sheykholeslami K, Habiby Kermany M, Hotta S, Kaga K. Time-
intensity trade of bilaterally bone-conducted sounds in normal hearing subjects.
European Review of ENT. 2003 , 124: 179-186.
Sheykholeslami K, Schmerber S, Habiby Kermany M, Kaga K. Bone-conducted binaural interaction in patient with bilateral atresia. International Journal of PediatricOto- Rhino-Laryngolgy, 2003. Oct;67(10):1083-90.
Arakawa M, Shiozuka M, Nakayama Y, Hara T, Hamada M, Kondo S, Ikeda D,
Takahashi Y, Sawa R, Nonomura Y, Sheykholeslami K, Kondo K, Kaga K, Kitamura T, Suzuki-Miyagoe Y, Takeda S, Matsuda R. Negamycin Restores Dystrophin Expression in Skeletal and Cardiac Muscles of mdx Mice. Journal of Biochemistry (Tokyo). 2003 Nov;134(5):751-8.
Schmerber S, Sheykholeslami K, Habiby Kermany M, Hotta S, Kaga K.Le facteur de compensation temps-intensité par conduction osseuse bilatérale chez des sujets normo-entendants. 2003, European Review of ENT (France).
Schmerber S, Sheykholeslami K, Habiby Kermany M, Hotta S, Kaga K. Time- intensity trade of bilaterally bone-conducted sounds in normal hearing subjects. Review in Laryngology, Otology and Rhinology (Bord). 2003;124 (3):179-85.
Sheykholeslami K, Schmerber S, Habiby Kermany M, Kaga K. Vestibular-evoked
myogenic potentials in patients with large vestibular aqueduct. Hearing Research. 2004
Apr;190 (1-2):161-8.
Sheykholeslami K. Auditory neuropathy: short notes. The Journal of Iranian Audiology. 2004.
Sheykholeslami K, Schmerber S, Habiby Kermany M, Kaga K. Sacculo-collic pathway dysfunction accompanying auditory neuropathy.
Acta Oto-layngologica. 2005 Jul;125(7):786-91.
Schmerber S, Sheykholeslami K, Habiby Kermany M, Hotta S, Kaga K. Time-intensity trading in bilateral congenital aural atresia patients.
Hearing Research. 2005 Apr; 202(1-2):248-57.
Sheykholeslami K, Megerian AC, Arnold EJ, Kaga K. Vestibular-evoked myogenic potentials in infancy and early childhood. Laryngoscope. 2005 Aug;115(8):1440-4
Liu Y, Okada T, Sheykholeslami K, Shimazaki K, Nomoto T, Muramatsu S, Kanazawa T, Takeuchi K, Ajalli R, Mizukami H, Kume A, Ichimura K, and Ozawa K. Specific and efficient transduction of cochlear inner hair cells with recombinant adeno-associated virus type 3 vector. Molecular. Therapy. 2005 Oct;12(4):725-33.
Mark Vecchiotti, MD.
Sulman CG, Vecchiotti MA, Semaan MT, Lewin JS, Megerian CA, Endolymphatic duct violation during retrosigmoid dissection of the internal auditory canal: a human temporal bone radiographic study, Laryngoscope, Nov, 2004; 114(11):1936-40.
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