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qyz@case.edu
Dr. Qing Yin Zheng is an assistant professor in the Department of Otolaryngology- Head and Neck Surgery, University Hospitals of Cleveland, Case Western Reserve University. He earned his Medical Degree at the Binzhou Medical College, his MS in Physiology at Xi'an Medical University. He completed his residency in Neurology in Capital University of Medical Sciences. He was a post doctoral fellow at The Jackson Laboratory (TJL), Bar Harbor, ME. Later, he was promoted to the position of a Research Scientist at TJL. He joined Case in 2006.
 The research in Dr. Zheng's laboratory focuses on a number of areas in genetics, genomics and proteomics of ear diseases in mice and humans. Although the human and mouse genomes have been sequenced, much still remains to be understood about how genes are regulated. Dr. Zheng has established a methodology combining genomics and proteomics to study gene expression in mouse inner ears. For example, he and his colleagues have developed a novel SSUMM approach (Subtractive Strategy Using Mouse Mutants, Zheng et al., Brain Research, 2006). SSUMM takes advantage of the differences between control and affected or mutant samples. SSUMM is a useful method in proteomics, especially in those cases in which the investigator must work with small numbers of diverse cell types from a tiny organ. The overall aim of these studies is to discover genes and molecular pathways that are involved in disease processes in mouse models of human deafness, including Otitis Media (OM) and Usher syndrome.
Selected Publications:
Keithley EM, Canto C, Zheng QY, Fischel-Ghodsian N, Johnson KR. Age-related hearing loss and the ahl locus in mice. Hear Res. 2004 Feb;188(1-2):21-8.
Lorenz-Depiereux B, Guido VE, Johnson KR, Zheng QY, Gagnon LH, Bauschatz JD, Davisson MT, Washburn LL, Donahue LR, Strom TM, Eicher EM. New intragenic deletions in the Phex gene clarify X-linked hypophosphatemia-related abnormalities in mice. Mamm Genome. 2004 Mar;15(3):151-61.
Zheng QY, Yan D, Ouyang XM, Du LL, Yu H, Chang B, Johnson KR, Liu XZ. Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans. Hum Mol Genet. 2005 Jan 1;14(1):103-11.
Johnson KR, Zheng QY, Weston MD, Ptacek LJ, Noben-Trauth K. The Mass1frings mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC. Genomics. 2005 May;85(5):582-90.
Longo-Guess CM, Gagnon LH, Cook SA, Wu J, Zheng QY, Johnson KR. A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7894-9.
Collin GB, Cyr E, Bronson R, Marshall JD, Gifford EJ, Hicks W, Murray SA, Zheng QY, Smith RS, Nishina PM, Naggert JK. Alms1-disrupted mice recapitulate human Alstrom syndrome. Hum Mol Genet. 2005 Aug 15;14(16):2323-33.
Zhang J, Peng Z, Yang M, Zhang X, Wei J, Xu M, Zheng QY. Observation of the morphology and calcium content of vestibular otoconia in rats after simulated weightlessness. Acta Otolaryngol. 2005 Oct;125(10):1039-42.
Keithley EM, Canto C, Zheng QY, Wang X, Fischel-Ghodsian N, Johnson KR. Cu/Zn superoxide dismutase and age-related hearing loss. Hear Res. 2005 Nov;209(1-2):76-85.
Jones SM, Jones TA, Johnson KR, Yu H, Erway LC, Zheng QY. A comparison of vestibular and auditory phenotypes in inbred mouse strains. Brain Res. 2006 May 26;1091(1):40-6.
Zhou X, Jen PH, Seburn KL, Frankel WN, Zheng QY. Auditory brainstem responses in 10 inbred strains of mice. Brain Res. 2006 May 26;1091(1):16-26.
Johnson KR, Zheng QY, Noben-Trauth K. Strain background effects and genetic modifiers of hearing in mice. Brain Res. 2006 May 26;1091(1):79-88.
Zheng QY, Rozanas CR, Thalmann I, Chance MR, Alagramam KN. Inner ear proteomics of mouse models for deafness, a discovery strategy. Brain Res. 2006 May 26;1091(1):113-21.
Zheng QY, Hardisty-Hughes R, Brown SD. Mouse models as a tool to unravel the genetic basis for human otitis media. Brain Res. 2006 May 26;1091(1):9-15.
Zheng QY, Yu H, Washington JL 3rd, Kisley LB, Kikkawa YS, Pawlowski KS ,Wright CG, Alagramam KN. A new spontaneous mutation in the mouse protocadherin 15 gene. Hear Res. 2006 Sep;219(1-2):110-20.
Zheng QY, Tong YC, Alagramam KN, Yu H. Tympanometry Assessment of 61 Inbred Strains of Mice. Hear Res. 2007 (In Press)
Recent Presentations
Zhang J, McCarty CM, Yu H, Giggey J Leah RB, Zheng QY. Molecular Pathogenesis of Otitis Media in a Mouse Model. The American Otological Society, April 27-28, 2007, Manchester Grand Hyatt, San Diego, CA
Zheng QY, Tong Y, Yu H, Li S, Alagramam K #130, Identify and Develop Mouse Models for Otitis Media, 30th Annual Midwinter Research Meeting of the Association for Research in Otolaryngology, February 10-15, 2007, Denver, Colorado, USA
Zheng QY, Yu H, Kisley L, Kikkawa Y, Pawlowski K, Wright C, Alagramam K, #743 Characterization of Pcdh15av-6J, an Allele of Mouse Protocadherin 15 Gene. 30th Annual Midwinter Research Meeting of the Association for Research in Otolaryngology, February 10-15, 2007, Denver , Colorado , USA .
Liu X, Yan D, Yu H, Longo-Guess C, Ouyang XM, Du LL, Kamiya K, Zheng QY. #780 Characterization of Knockout Mouse Model for Usher Syndrome Type 1C, 30th Annual MidWinter Research Meeting of the Association for Research in Otolaryngology, February 10-15, 2007, Denver , Colorado , USA
Megerian CA, Semaan MT, Aftab S, Kisley LB, Zheng QY , Pawlowski KS, Wright CG, and Alagramam, KN. A mouse model with postnatal endolymphatic hydrops and hearing loss. Hear Res. 2008 in press.
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Zheng QY, Ding DL; Yu H; Salvi RJ and Johnson KR. A locus on distal Chromosome 10 ( ahl4 ) affecting age-related hearing loss in A/J mice. Neurobiology of Aging, In press.
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Li S, Zhang SQ, Liu SW, Li BY, Zhu HL, Yu H and Zheng QY . Assessment Criteria for Rotated Stereociliary Bundles in the Guinea Pig Cochlea. Otology & Neurotology. 2008 Jan;29(1):86-92
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Zhang J, Kaga k, Zheng QY. Small papillary tumor in the saccule. Int J Pediatr Otorhinolaryngol Extra. (2007) 2, 107-110
Johnson KR, Zheng QY , Noben-Trauth K. Strain background effects and genetic modifiers of hearing in mice. Brain Res. 2006 May 26;1091(1):79-88
Zheng QY , Harris BS, Yu H, Letts VA, Ward-Bailey P, Bronson RT, Davisson MT, Johnson KR. 2004. Fine Mapping of a Deafness Mutation hml on Mouse Chromosome 10. Academic Journal of Xi'an Jiaotong University 25(2):105-109.
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Zheng QY , Johnson KR. 2003. Mouse models for otitis media. Journal of Xi'an Jiaotong University (Medical Sciences) 24(6):521-526.
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Johnson KR, Gagnon LH, Webb LS, Peters LL, Hawes NL, Chang B, Zheng QY . 2003 Mouse models of USH1C and DFNB18: phenotypic and molecular analyses of two new spontaneous mutations of the Ush1c gene. Hum Molecular Genetics 12(23):3075-86.
Donahue LR, Chang B, Subburaman M, Miyakoshi N, Wergedal JE, Baylink DJ, Hawes NL, Rosen CJ, Ward-Bailey P, Zheng QY , Bronson RT, Johnson KR, Davisson MT. 2003. A missense mutation in the mouse Col2a1 gene causes spondyloepiphyseal dysplasia, hearing loss, and retinoschisis. Journal of Bone and Mineral Research, 18(9):1612-21.
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Noben-Trauth K, Zheng QY and Johnson KR. 2003. Association of cadherin-23 with polygenic inheritance and genetic modification of sensorineural hearing loss. Nature Genetics 35, 21 - 23.
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Johnson KR and Zheng QY . 2002. Ahl2 , A second locus affecting age-related hearing loss in mice. Genomics 80(5):461-4.
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Ikeda A, Zheng QY , Zuberi AR, Johnson KR, Naggert KJ and Nishina PM. 2002. Microtubule-associated protein 1A is a modifier of tubby hearing ( moth1 ). Nature Genetics 30(4):401-405
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Young KA, Berry ML, Mahaffey CL, Saionz JR, Hawes NL, Chang B, Zheng QY , Smith RS, Bronson RT, Nelson RJ, Simpson EM. 2002. Fierce: A new mouse deletion of Nr2e1; violent behavior and ocular abnormalities are background-dependent. Behav Brain Res, 14;132(2):145-58.
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Staecker H, Zheng QY , Van De Water TR. 2001. Oxidative stress in aging in the C57B16/J mouse cochlea. Acta Otolaryngol 2001 Sep;121(6):666-72.
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Zheng QY and Johnson KR. 2001. Hearing loss associated with the modifier of deaf waddler ( mdfw ) locus corresponds with age-related hearing loss in 12 inbred strains of mice. Hear Res 154: 45-53.
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Johnson KR, Zheng QY , Bykhovskaya Y, Spirina O, Fishel-Ghodsian, N. 2001. A nuclear-mitochondrial interaction affecting hearing impairment in mice. Nature Genetics 27(2):191-194.
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Munroe RJ, Bergstrom RA, Zheng QY , Smith RS, John SW, Frankel WF, Schimenti KJ, Tarantino L, Bucan M, Browning VL, Schimenti JC. 2000. Mouse mutants from chemically mutagenized embryonic stem cells. Nature Genetics 24(3):318-21.
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Letts, VA, Valenzuela, A, Dunbar, C, Zheng QY , Johnson KR and Frankel WN. 2000. A new spontaneous mouse mutation in the Kcne1 gene. Mamm Genome 11(10):831-835.
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Johnson KR, Zheng QY , Erway LC. 2000. A major gene affecting age-related hearing loss is common to at least ten inbred strains of mice. Genomics 70(2):171-180.
Lab members
- Cindy Benedict-Alderfer, Ph.D. Research Specialist
- Heping Yu, BS, Research Assistant 4
- Chunling Gu, Technician 1
- Baiya Li, M.D., Ph.D. Student
- Shengli Li, MD, Visiting Scientist
- Fenchan Han, MD, Ph.D. Postdoctoral Research Associate
- Cong Tian, B.S., Research Scholar
- Kia Sheykholeslami, M.D., PGY4 – Resident Scientist
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